Contulakin-G
Also known as: CG, Conotoxin G, Contulakin-G
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Summary
Contulakin‑G is a 16‑amino‑acid peptide isolated from the venom of Conus geographus. It mimics neurotensin, activates NTS1 receptors, and has been studied as a non‑opioid analgesic for acute and neuropathic pain.
Mechanism of Action
Agonist of neurotensin receptor 1 (NTS1) leading to modulation of spinal pain pathways and analgesia
Routes of Administration
Goals & Uses
- Acute postoperative pain reliefAnalgesiaModerate
- Neuropathic pain managementAnalgesiaLow
Contraindications
- Known hypersensitivity to the peptideAllergyHigh
- Severe cardiovascular diseaseCardiovascularModerate
Adverse Effects
- HeadacheNeurologicUncommonPain in the head or upper neck
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- DizzinessNeurologicCommonFeeling faint, lightheaded, or unsteady
Drug Interactions
- CNS depressants (e.g., benzodiazepines)Moderate
- Opioid analgesicsModerate
Population Constraints
- Pregnant womenReproductiveRelative
- Children <12 yearsAgeRelative
Regulatory Status
- European UnionInvestigationalUnder clinical evaluation; not authorized by EMA.
- United StatesInvestigationalInvestigational New Drug (IND) application filed; not FDA‑approved.
Not approved by any regulatory agency; investigated in Phase I/II clinical trials for postoperative pain. No scheduled or controlled‑substance designation.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Contulakin-G?
Contulakin‑G is a 16‑amino‑acid peptide isolated from the venom of Conus geographus. It mimics neurotensin, activates NTS1 receptors, and has been studied as a non‑opioid analgesic for acute and neuropathic pain.
What is Contulakin-G used for?
Contulakin-G is educationally associated with: Acute postoperative pain relief, Neuropathic pain management. Educational only — not medical advice.
How is Contulakin-G administered?
Recorded routes of administration: Intrathecal, Intravenous, Subcutaneous.
What are the potential side effects of Contulakin-G?
Reported adverse effects include: Headache, Nausea, Dizziness. This list is not exhaustive — consult a qualified clinician.
Who should avoid Contulakin-G?
Recorded contraindications: Known hypersensitivity to the peptide, Severe cardiovascular disease. Consult a qualified clinician before use.