Kisspeptin
Also known as: KISS1, KISS1 peptide, Kisspeptin-10, Kisspeptin-54, KP-10, KP-54, Metastin
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Summary
Kisspeptin is an endogenous 54‑amino‑acid peptide that regulates the hypothalamic‑pituitary‑gonadal axis and has anti‑metastatic properties; investigated for fertility disorders and certain cancers.
Mechanism of Action
Activates the G-protein-coupled receptor KISS1R (GPR54), stimulating GnRH release and downstream LH/FSH secretion; also modulates metastasis signaling pathways.
Routes of Administration
Goals & Uses
- Tumor metastasis suppression (anti-metastatic)OncologyLow
- Diagnosis of GnRH deficiency (functional test)Diagnostic EndocrinologyModerate
- Induction of ovulationReproductiveModerate
- Suppression of tumor metastasisOncologyLow
- Treatment of hypogonadotropic hypogonadismEndocrinologyModerate
- Improvement of sexual arousal / libidoSexual MedicineLow
- Restoration of reproductive function in hypothalamic amenorrheaReproductive MedicineModerate
- Induction of ovulation / oocyte maturation trigger in IVFReproductive MedicineModerate
Contraindications
- Hormone-sensitive malignanciesOncologyHigh
- Known hypersensitivity to kisspeptin or excipientsAllergy/ImmunologyHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Severe cardiovascular diseaseCardiovascularModerate
- Pituitary insufficiencyEndocrinologyModerate
- Pregnancy (outside of controlled IVF protocols)ObstetricsModerate
Adverse Effects
- Injection site reactionsLocalCommon
- HeadacheNeurologicCommonPain in the head or upper neck
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- Transient decrease in blood pressureCardiovascularUncommon
- Hot flushesVasomotorUncommon
- Ovarian hyperstimulation syndrome (OHSS)ReproductiveRare
Drug Interactions
- GnRH agonists / antagonists (e.g., leuprolide, cetrorelix)Moderate
- Exogenous gonadotropins (FSH, LH, hCG)Moderate
- OpioidsLow
- Opioid analgesicsModerate
Population Constraints
- Pediatric populations (prepubertal)AgeRelative
- Pediatric patientsAgeRelative
- Elderly (>75)AgeRelative
- Patients with active endometriosisGynecologicalRelative
- BreastfeedingReproductiveRelative
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionInvestigationalClinical studies ongoing for infertility treatment
- United StatesInvestigationalPhase I/II trials for hypogonadotropic hypogonadism
- United KingdomInvestigationalResearch use only
No jurisdiction has granted full marketing approval for any kisspeptin therapeutic as of 2024. Used as an investigational agent in clinical trials; kisspeptin-54 has been studied in Phase I/II trials in the UK (Imperial College London) and elsewhere for reproductive indications.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Kisspeptin?
Kisspeptin is an endogenous 54‑amino‑acid peptide that regulates the hypothalamic‑pituitary‑gonadal axis and has anti‑metastatic properties; investigated for fertility disorders and certain cancers.
What is Kisspeptin used for?
Kisspeptin is educationally associated with: Tumor metastasis suppression (anti-metastatic), Diagnosis of GnRH deficiency (functional test), Induction of ovulation, Suppression of tumor metastasis, Treatment of hypogonadotropic hypogonadism, Improvement of sexual arousal / libido, Restoration of reproductive function in hypothalamic amenorrhea, Induction of ovulation / oocyte maturation trigger in IVF. Educational only — not medical advice.
How is Kisspeptin administered?
Recorded routes of administration: Intranasal, Intravenous, Subcutaneous.
What are the potential side effects of Kisspeptin?
Reported adverse effects include: Injection site reactions, Headache, Nausea, Transient decrease in blood pressure, Hot flushes, Ovarian hyperstimulation syndrome (OHSS). This list is not exhaustive — consult a qualified clinician.
Who should avoid Kisspeptin?
Recorded contraindications: Hormone-sensitive malignancies, Known hypersensitivity to kisspeptin or excipients, Pregnancy, Severe cardiovascular disease, Pituitary insufficiency, Pregnancy (outside of controlled IVF protocols). Consult a qualified clinician before use.