Vasoactive intestinal peptide
Also known as: Aviptadil, PHI-27, RLF-100, Vasoactive intestinal polypeptide, VIP
Source Vasoactive intestinal peptide at Peptiology
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Summary
Endogenous 28‑amino‑acid peptide that regulates vascular tone, airway function, gastrointestinal secretion and immune responses.
Mechanism of Action
Binds VPAC1 and VPAC2 G‑protein‑coupled receptors, activating adenylate cyclase → ↑cAMP → smooth‑muscle relaxation, vasodilation, bronchodilation, glandular secretion and immunomodulation.
Routes of Administration
Goals & Uses
- Erectile dysfunctionSexual HealthModerate
- Immunomodulation / autoimmune diseaseImmunologyLow
- Sjogren's syndromeAutoimmuneLow
- Acute Respiratory Distress Syndrome (ARDS)RespiratoryModerate
- COVID‑19 ARDSRespiratoryLow
- Inflammatory bowel diseaseGastroenterologyLow
- Pulmonary hypertensionCardiovascularModerate
- Bronchospasm / asthmaPulmonaryLow
- Pulmonary arterial hypertensionCardiovascular / PulmonaryModerate
Contraindications
- Known hypersensitivity to peptide formulationsAllergyModerate
- Known hypersensitivity to VIP or excipientsAllergyHigh
- VIPoma / known VIP-secreting tumorOncology / EndocrinologyModerate
- Severe hypotensionCardiovascularHigh
Adverse Effects
- Nausea / gastrointestinal discomfortGastrointestinalUncommon
- Facial flushingCardiovascular/DermatologicCommon
- Injection site reactionsLocalCommon
- HeadacheNeurologicUncommonPain in the head or upper neck
- HypotensionCardiovascularCommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- TachycardiaCardiovascularCommonAbnormally fast heart rate
- Bronchospasm (paradoxical, inhalation route)PulmonaryRare
- DiarrheaGastrointestinalUncommonLoose or frequent stools
Drug Interactions
- Antihypertensive agentsModerate
- Beta‑blockersLow
- Other vasodilators (e.g., nitroglycerin)Moderate
- Beta-blockersLow
- Phosphodiesterase-5 inhibitors (e.g., sildenafil)Moderate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionInvestigationalClinical trials ongoing; not authorized for marketing.
- United StatesInvestigationalInvestigational New Drug (IND) applications filed; no approved product.
- United KingdomInvestigationalNo MHRA-approved indication. Under investigation in clinical trials.
No FDA‑approved product; studied as investigational therapeutic (e.g., Aviptadil) for pulmonary hypertension, ARDS, and inflammatory diseases.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Vasoactive intestinal peptide?
Endogenous 28‑amino‑acid peptide that regulates vascular tone, airway function, gastrointestinal secretion and immune responses.
What is Vasoactive intestinal peptide used for?
Vasoactive intestinal peptide is educationally associated with: Erectile dysfunction, Immunomodulation / autoimmune disease, Sjogren's syndrome, Acute Respiratory Distress Syndrome (ARDS), COVID‑19 ARDS, Inflammatory bowel disease, Pulmonary hypertension, Bronchospasm / asthma, Pulmonary arterial hypertension. Educational only — not medical advice.
How is Vasoactive intestinal peptide administered?
Recorded routes of administration: Inhalation, Intranasal, Intravenous, Subcutaneous.
What are the potential side effects of Vasoactive intestinal peptide?
Reported adverse effects include: Nausea / gastrointestinal discomfort, Facial flushing, Injection site reactions, Headache, Hypotension, Flushing, Tachycardia, Bronchospasm (paradoxical, inhalation route), Diarrhea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Vasoactive intestinal peptide?
Recorded contraindications: Known hypersensitivity to peptide formulations, Known hypersensitivity to VIP or excipients, VIPoma / known VIP-secreting tumor, Severe hypotension. Consult a qualified clinician before use.