CTCE-0214
Also known as: CTCE‑0214, CXCL12 analog
Source CTCE-0214 at Peptiology
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Summary
CTCE‑0214 is a synthetic peptide derived from the N‑terminus of CXCL12 that acts as a CXCR4 antagonist. It has been investigated for stem‑cell mobilization and myocardial repair in preclinical and early‑phase clinical studies.
Mechanism of Action
Competitive inhibition of the CXCR4 receptor, preventing binding of its natural ligand CXCL12 (SDF‑1α) and downstream G‑protein signaling.
Routes of Administration
Goals & Uses
- Myocardial repairCardiovascularModerate
- Stem cell mobilizationHematopoietic Stem Cell TransplantationModerate
Contraindications
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Severe uncontrolled hypertensionCardiovascularHigh
Adverse Effects
- Injection site painLocalCommonPain at the injection site
- Transient hypotensionCardiovascularUncommon
Drug Interactions
- Beta‑blockersModerate
Population Constraints
- Pediatric patientsAgeRelative
Regulatory Status
- European UnionInvestigationalNo marketing authorization granted.
- United StatesInvestigationalPhase I/II clinical trials ongoing.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is CTCE-0214?
CTCE‑0214 is a synthetic peptide derived from the N‑terminus of CXCL12 that acts as a CXCR4 antagonist. It has been investigated for stem‑cell mobilization and myocardial repair in preclinical and early‑phase clinical studies.
What is CTCE-0214 used for?
CTCE-0214 is educationally associated with: Myocardial repair, Stem cell mobilization. Educational only — not medical advice.
How is CTCE-0214 administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of CTCE-0214?
Reported adverse effects include: Injection site pain, Transient hypotension. This list is not exhaustive — consult a qualified clinician.
Who should avoid CTCE-0214?
Recorded contraindications: Pregnancy, Severe uncontrolled hypertension. Consult a qualified clinician before use.