FOXO4-DRI
Also known as: ALM-201, FOX04-DRI, FOXO4-D-Retro-Inverso, senolytic peptide 1
Source FOXO4-DRI at Peptiology
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Summary
Synthetic peptide designed to selectively eliminate senescent cells by interfering with the FOXO4-p53 axis, promoting p53-mediated apoptosis in aged/damaged cells while sparing healthy cells
Mechanism of Action
Disrupts FOXO4-p53 interaction to induce apoptosis in senescent cells by preventing nuclear retention of active p53
Routes of Administration
Goals & Uses
- tissue regenerationRegenerative MedicineLow
- frailty reductionGeriatricsModerate
- senolytic therapyAnti AgingModerate
- nephroprotectionOrgan ProtectionModerate
- cardiovascular_diseaseCardiologyLow
Contraindications
- immunodeficiencyImmunologyModerate
- active_malignancyOncologyHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
Adverse Effects
- immune_reactionImmunogenicityUnknown
- off-target_cell_deathToxicityUnknown
- injection_site_reactionLocalCommon
Drug Interactions
- senolytics_dasatinib_quercetinLow
- chemotherapy_agentsModerate
Population Constraints
- pediatric_populationAgeAbsolute
- elderly_frailAgeRelative
Regulatory Status
- European UnionUnapprovedNo EMA approval; research use only
- United StatesUnapprovedNot submitted for FDA approval; research use only
Not approved for human use; preclinical and early clinical research ongoing for age-related diseases
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is FOXO4-DRI?
Synthetic peptide designed to selectively eliminate senescent cells by interfering with the FOXO4-p53 axis, promoting p53-mediated apoptosis in aged/damaged cells while sparing healthy cells
What is FOXO4-DRI used for?
FOXO4-DRI is educationally associated with: tissue regeneration, frailty reduction, senolytic therapy, nephroprotection, cardiovascular_disease. Educational only — not medical advice.
How is FOXO4-DRI administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of FOXO4-DRI?
Reported adverse effects include: immune_reaction, off-target_cell_death, injection_site_reaction. This list is not exhaustive — consult a qualified clinician.
Who should avoid FOXO4-DRI?
Recorded contraindications: immunodeficiency, active_malignancy, Pregnancy. Consult a qualified clinician before use.