Glutathionylspermidine
Also known as: Glutathione-spermidine conjugate, Gsp, N1-(L-gamma-glutamyl-L-cysteinylglycyl)spermidine
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Summary
Endogenous low‑molecular‑weight conjugate of glutathione and spermidine found in many organisms; implicated in oxidative‑stress response and polyamine metabolism.
Mechanism of Action
Glutathionylspermidine is formed by the enzymatic conjugation of glutathione to spermidine via glutathionylspermidine synthetase/amidase (GspSA). It serves as an intermediate in trypanothione biosynthesis in trypanosomatids and acts as a thiol metabolite involved in redox homeostasis and protection against oxidative stress. In bacteria such as E. coli, it accumulates under acidic stress conditions and may serve as a reservoir for both glutathione and spermidine.
Routes of Administration
Goals & Uses
- Acid stress response studyResearchModerate
- Antiparasitic drug target researchResearchModerate
- Redox homeostasis researchResearchModerate
Contraindications
No contraindications recorded yet.
Adverse Effects
No adverse effects recorded yet.
Drug Interactions
No drug interactions recorded yet.
Population Constraints
No population constraints recorded yet.
Regulatory Status
- European UnionUnapprovedResearch compound only; not evaluated by EMA.
- United StatesUnapprovedNot an approved drug; studied as a biomarker.
- United KingdomUnapprovedResearch compound only; not evaluated by MHRA.
Not approved by any regulatory authority (FDA, EMA, MHRA) for any clinical indication. Purely a research compound and endogenous metabolite studied in microbiology and antiparasitic drug discovery.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Glutathionylspermidine?
Endogenous low‑molecular‑weight conjugate of glutathione and spermidine found in many organisms; implicated in oxidative‑stress response and polyamine metabolism.
What is Glutathionylspermidine used for?
Glutathionylspermidine is educationally associated with: Acid stress response study, Antiparasitic drug target research, Redox homeostasis research. Educational only — not medical advice.
How is Glutathionylspermidine administered?
Recorded routes of administration: Not Applicable (endogenous Metabolite; Not Administered Clinically).