Interleukin-10
Also known as: CSIF (Cytokine Synthesis Inhibitory Factor), IL-10, Ilodecakin, Interleukin 10, Pegilodecakin, rIL-10, Tenovil
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Summary
Recombinant human Interleukin‑10 is a cytokine used experimentally to modulate immune responses, with applications in inflammatory disease and oncology.
Mechanism of Action
Binds IL-10 receptor (IL-10R1/IL-10R2) activating JAK1/TYK2 → STAT3 signaling, suppresses pro‑inflammatory cytokine production and enhances regulatory immune functions
Routes of Administration
Goals & Uses
- PsoriasisDermatology / InflammatoryModerate
- Inflammatory bowel disease / Crohn's diseaseAutoimmune / InflammatoryModerate
- autoimmune disease controlAutoimmunityLow
- anti‑inflammatory therapyImmunomodulationModerate
- Rheumatoid arthritisAutoimmune DiseaseLow
- Sepsis / systemic inflammationCritical CareLow
- Cancer immunotherapyOncologyModerate
Contraindications
- known hypersensitivity to IL‑10 or formulation componentsAllergyHigh
- Severe immunodeficiencyImmunologyHigh
- Active severe infectionInfectiousModerate
- Hypersensitivity to IL-10 or recombinant human proteinsAllergy / ImmunologyHigh
- Active severe infectionsInfectious DiseaseHigh
Adverse Effects
- hematologic abnormalities (anemia, thrombocytopenia)HematologicUncommon
- Injection site reactionsLocalCommon
- Anemia / thrombocytopeniaHematologicCommon
- Flu-like symptoms (fever, chills, myalgia)SystemicCommon
- Flu‑like syndromeSystemicCommon
- Autoantibody inductionImmunologicUncommon
- Opportunistic infectionsInfectiousUncommon
- Injection site reactionLocalCommonRedness, swelling, itching, bruising, or pain at the injection site
- Elevated liver enzymesHepaticUncommonIncrease in AST/ALT or other hepatic markers
Drug Interactions
- Live vaccinesHigh
- Biologics / TNF inhibitorsModerate
- Chemotherapeutic agentsLow
- CorticosteroidsModerate
- Immunosuppressants (e.g., cyclosporine, methotrexate)Moderate
Population Constraints
- PregnancyReproductive SafetyRelative
- Patients with active malignancyOncologyRelative
- Pediatric populationsAgeRelative
- Pediatric patientsAgeRelative
- Elderly patientsAgeRelative
Regulatory Status
- European UnionInvestigationalClinical studies ongoing; not authorized for marketing
- United StatesInvestigationalPhase I/II trials for solid tumors and inflammatory disorders
- United KingdomUnknownNo approved indication; research use only.
Recombinant human IL-10 (ilodecakin) was investigated by Schering-Plough but not approved by FDA or EMA for any indication. Pegilodecakin (AM0010) received FDA Fast Track designation for certain cancers but failed Phase III trials. No approved therapeutic formulation exists as of 2024.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Interleukin-10?
Recombinant human Interleukin‑10 is a cytokine used experimentally to modulate immune responses, with applications in inflammatory disease and oncology.
What is Interleukin-10 used for?
Interleukin-10 is educationally associated with: Psoriasis, Inflammatory bowel disease / Crohn's disease, autoimmune disease control, anti‑inflammatory therapy, Rheumatoid arthritis, Sepsis / systemic inflammation, Cancer immunotherapy. Educational only — not medical advice.
How is Interleukin-10 administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of Interleukin-10?
Reported adverse effects include: hematologic abnormalities (anemia, thrombocytopenia), Injection site reactions, Anemia / thrombocytopenia, Flu-like symptoms (fever, chills, myalgia), Flu‑like syndrome, Autoantibody induction, Opportunistic infections, Injection site reaction, Elevated liver enzymes. This list is not exhaustive — consult a qualified clinician.
Who should avoid Interleukin-10?
Recorded contraindications: known hypersensitivity to IL‑10 or formulation components, Severe immunodeficiency, Active severe infection, Hypersensitivity to IL-10 or recombinant human proteins, Active severe infections. Consult a qualified clinician before use.