Kisspeptin-10
Also known as: KISS1 decapeptide, Kisspeptin 112-121, Kisspeptin‑10, KP-10, KP‑10, Metastin (10-19), Metastin(10)
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Summary
Kisspeptin‑10 (KP‑10) is a 10‑amino‑acid fragment of the native kisspeptin peptide that potently activates KISS1R, regulating the hypothalamic‑pituitary‑gonadal axis and exhibiting metastasis‑suppressor activity in preclinical cancer models.
Mechanism of Action
Agonist of the G protein‑coupled receptor KISS1R (GPR54), activating Gq/PLC/IP3 signaling and stimulating GnRH release from hypothalamic neurons
Routes of Administration
Goals & Uses
- Stimulation of LH and FSH secretionReproductive EndocrinologyHigh
- ContraceptionReproductiveLow
- Infertility treatmentReproductiveModerate
- Treatment of hypogonadotropic hypogonadismEndocrinologyModerate
- Treatment of hypothalamic amenorrheaReproductive EndocrinologyModerate
- Oocyte maturation trigger in ARTFertility / Assisted ReproductionModerate
- Tumor suppression / anti-metastatic effectsOncologyLow
- Assessment of HPG axis integrity (diagnostic)DiagnosticsModerate
- Metastasis suppressionOncologyModerate
Contraindications
- Hormone-sensitive malignanciesOncologyHigh
- Known hypersensitivity to kisspeptin or excipientsAllergy/ImmunologyHigh
- Ovarian hyperstimulation syndrome (OHSS) risk — caution in ARTReproductive EndocrinologyModerate
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Pregnancy (outside of intended ART trigger use)ReproductiveModerate
- Hormone‑sensitive cancersOncologyModerate
Adverse Effects
- Injection site reactionsLocalCommon
- HeadacheNeurologicCommonPain in the head or upper neck
- Ovarian hyperstimulation syndromeReproductive / EndocrineRare
- FlushingVascularUncommonWarmth and redness of the skin
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- Transient flushingVasomotorUncommon
Drug Interactions
- Sex steroid hormones (estrogen, testosterone, progesterone)Low
- Estrogen therapyLow
- Gonadotropins (FSH, LH, hCG)Moderate
- GnRH analogues (agonists/antagonists)Moderate
- GnRH analoguesModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Patients with history of hormone-sensitive cancerOncologyRelative
- Pediatric patients (prepubertal)AgeRelative
- Pregnant womenReproductiveAbsolute
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionInvestigationalEarly clinical studies ongoing.
- United StatesInvestigationalPhase I/II trials for infertility.
- United KingdomInvestigationalResearch use only.
Not approved for any therapeutic indication; used only in clinical research and early‑phase trials.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Kisspeptin-10?
Kisspeptin‑10 (KP‑10) is a 10‑amino‑acid fragment of the native kisspeptin peptide that potently activates KISS1R, regulating the hypothalamic‑pituitary‑gonadal axis and exhibiting metastasis‑suppressor activity in preclinical cancer models.
What is Kisspeptin-10 used for?
Kisspeptin-10 is educationally associated with: Stimulation of LH and FSH secretion, Contraception, Infertility treatment, Treatment of hypogonadotropic hypogonadism, Treatment of hypothalamic amenorrhea, Oocyte maturation trigger in ART, Tumor suppression / anti-metastatic effects, Assessment of HPG axis integrity (diagnostic), Metastasis suppression. Educational only — not medical advice.
How is Kisspeptin-10 administered?
Recorded routes of administration: Intranasal, Intravenous, Subcutaneous.
What are the potential side effects of Kisspeptin-10?
Reported adverse effects include: Injection site reactions, Headache, Ovarian hyperstimulation syndrome, Flushing, Nausea, Transient flushing. This list is not exhaustive — consult a qualified clinician.
Who should avoid Kisspeptin-10?
Recorded contraindications: Hormone-sensitive malignancies, Known hypersensitivity to kisspeptin or excipients, Ovarian hyperstimulation syndrome (OHSS) risk — caution in ART, Pregnancy, Pregnancy (outside of intended ART trigger use), Hormone‑sensitive cancers. Consult a qualified clinician before use.