KPV
Also known as: alpha-MSH(11-13), KPV tripeptide, Lys-Pro-Val, Lysine-Proline-Valine
Source KPV at Peptiology
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Summary
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) with potent anti-inflammatory properties. It lacks the melanotropic activity of full-length α-MSH while retaining immunomodulatory effects, making it a candidate for inflammatory and autoimmune conditions.
Mechanism of Action
alpha-MSH derivative with anti-inflammatory and immunomodulatory effects; acts via MC1R-independent pathways, inhibiting NF-κB activation and reducing pro-inflammatory cytokine production
Routes of Administration
Goals & Uses
- Autoimmune disease modulationImmunologyLow
- Wound healingDermatologicModerateTissue repair and wound healing
- Anti-inflammatory therapyTherapeuticModerate
- Cosmetic/dermatologicalTherapeuticLow
Contraindications
- Active malignancyOncologyModerateUse caution or avoid depending on agent and context
- hypersensitivity to peptide componentsAllergyModerate
Adverse Effects
- Local injection site reactionLocalUnknown
- Immunosuppression-related infectionImmunologicalUnknown
Drug Interactions
- Immunosuppressants (biologics)Moderate
- CorticosteroidsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric populationsAgeRelative
- Severe immunocompromiseImmunologicalRelative
Regulatory Status
- European UnionUnapprovedNo MAA submitted; not listed in EMA databases
- United StatesUnapprovedNo IND or NDA filed; research use only
- United KingdomUnapprovedNo UK marketing authorization; MHRA database negative
Not approved for any indication; remains in preclinical and early research phases. No formal regulatory submissions identified.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is KPV?
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) with potent anti-inflammatory properties. It lacks the melanotropic activity of full-length α-MSH while retaining immunomodulatory effects, making it a candidate for inflammatory and autoimmune conditions.
What is KPV used for?
KPV is educationally associated with: Autoimmune disease modulation, Wound healing, Anti-inflammatory therapy, Cosmetic/dermatological. Educational only — not medical advice.
How is KPV administered?
Recorded routes of administration: Intravenous, Oral, Subcutaneous, Topical.
What are the potential side effects of KPV?
Reported adverse effects include: Local injection site reaction, Immunosuppression-related infection. This list is not exhaustive — consult a qualified clinician.
Who should avoid KPV?
Recorded contraindications: Active malignancy, hypersensitivity to peptide components. Consult a qualified clinician before use.