Pentigetide
Also known as: Gly-Orn-Ser-Ser-Pro, IgE pentapeptide, Pentyde
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Summary
Pentigetide (also known as Gly-Orn-Ser-Ser-Pro) is a synthetic pentapeptide derived from the Fc region of IgE. It was investigated primarily for allergic rhinitis and other IgE-mediated allergic conditions via intranasal administration. Clinical development was discontinued due to insufficient efficacy in pivotal trials.
Mechanism of Action
Inhibits IgE-mediated allergic responses by competitively binding to IgE receptors on mast cells and basophils, thereby preventing IgE-triggered degranulation and release of histamine and other mediators.
Routes of Administration
Goals & Uses
- Allergic rhinitis symptom reductionAllergy / ImmunologyLow
- Mast cell stabilizationAnti InflammatoryLow
- IgE-mediated allergy suppressionImmunomodulationLow
Contraindications
- Hypersensitivity to pentigetide or peptide componentsAllergyHigh
Adverse Effects
- Nasal irritationLocal/NasalCommon
- SneezingLocal ReactionCommon
- HeadacheNeurologicUncommonPain in the head or upper neck
Drug Interactions
- AntihistaminesLow
Population Constraints
- Pediatric patientsAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionUnapprovedNo EMA marketing authorization granted. Not commercially available.
- United StatesUnapprovedInvestigated in clinical trials; FDA approval never obtained. Development discontinued.
Pentigetide was investigated in the US and other jurisdictions but was never approved by the FDA or EMA. Development was halted after Phase II/III trials failed to demonstrate adequate clinical benefit.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Pentigetide?
Pentigetide (also known as Gly-Orn-Ser-Ser-Pro) is a synthetic pentapeptide derived from the Fc region of IgE. It was investigated primarily for allergic rhinitis and other IgE-mediated allergic conditions via intranasal administration. Clinical development was discontinued due to insufficient efficacy in pivotal trials.
What is Pentigetide used for?
Pentigetide is educationally associated with: Allergic rhinitis symptom reduction, Mast cell stabilization, IgE-mediated allergy suppression. Educational only — not medical advice.
How is Pentigetide administered?
Recorded routes of administration: Nasal.
What are the potential side effects of Pentigetide?
Reported adverse effects include: Nasal irritation, Sneezing, Headache. This list is not exhaustive — consult a qualified clinician.
Who should avoid Pentigetide?
Recorded contraindications: Hypersensitivity to pentigetide or peptide components. Consult a qualified clinician before use.