S-(2,4-dinitrophenyl)glutathione
Also known as: DNP-SG, DNPH‑glutathione, Glutathione-DNP conjugate, GS-DNP, GSH‑DNP, S-(2,4-dinitrophenyl)-glutathione
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Summary
S-(2,4-dinitrophenyl)glutathione is a glutathione derivative bearing a 2,4-dinitrophenyl group on its thiol. It is employed chiefly as a hapten for antibody production and assay development, not as a therapeutic agent.
Mechanism of Action
acts as a hapten; forms antigenic complexes that elicit antibody responses in immunological studies
Routes of Administration
No administration routes recorded yet.
Goals & Uses
- Multidrug resistance investigationResearch / OncologyModerate
- GST activity measurementResearch / Biochemical AssayHigh
- Cellular detoxification pathway studiesResearch / ToxicologyModerate
- MRP1/MRP2 transport characterizationResearch / Transporter BiologyHigh
Contraindications
- Human therapeutic useRegulatory/safetyHigh
Adverse Effects
- Cytotoxicity (in vitro)ToxicityCommon
Drug Interactions
- MRP1/ABCC1 inhibitors (e.g., MK-571)Low
Population Constraints
- All human populationsGeneralAbsolute
Regulatory Status
- European UnionUnapprovedNo EMA regulatory status; used solely as a laboratory biochemical.
- United StatesUnapprovedResearch reagent only; not reviewed or approved by the FDA for any therapeutic indication.
- United KingdomUnapprovedNo MHRA regulatory status; research use only.
No regulatory approval in any jurisdiction. Used exclusively as a biochemical research reagent. Not intended for human or veterinary therapeutic use.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is S-(2,4-dinitrophenyl)glutathione?
S-(2,4-dinitrophenyl)glutathione is a glutathione derivative bearing a 2,4-dinitrophenyl group on its thiol. It is employed chiefly as a hapten for antibody production and assay development, not as a therapeutic agent.
What is S-(2,4-dinitrophenyl)glutathione used for?
S-(2,4-dinitrophenyl)glutathione is educationally associated with: Multidrug resistance investigation, GST activity measurement, Cellular detoxification pathway studies, MRP1/MRP2 transport characterization. Educational only — not medical advice.
What are the potential side effects of S-(2,4-dinitrophenyl)glutathione?
Reported adverse effects include: Cytotoxicity (in vitro). This list is not exhaustive — consult a qualified clinician.
Who should avoid S-(2,4-dinitrophenyl)glutathione?
Recorded contraindications: Human therapeutic use. Consult a qualified clinician before use.