S-Methyl glutathione
Also known as: GSMe, S-Me-GSH, S-Methylglutathione, S‑Methyl‑GSH, S‑Methylglutathione, γ-L-Glutamyl-S-methyl-L-cysteinylglycine
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Summary
S-Methylglutathione is a methylated analogue of the endogenous tripeptide glutathione (γ‑glutamyl‑cysteinyl‑glycine), where the cysteine thiol is methylated. It occurs as a metabolic product and is used primarily as a biochemical marker rather than a therapeutic agent.
Mechanism of Action
S-Methyl glutathione is a methylated derivative of glutathione (γ-L-glutamyl-L-cysteinyl-glycine) in which the thiol group of the cysteine residue is methylated. It acts as a stable glutathione analog, potentially modulating redox homeostasis, supporting antioxidant defense, and serving as a substrate or inhibitor in glutathione-dependent enzymatic pathways including glutathione S-transferases.
Routes of Administration
Goals & Uses
- Glutathione metabolism tracerMetabolic ResearchModerate
- Glutathione S-transferase substrate/inhibitor researchEnzymologyModerate
- Antioxidant defense modulationBiochemical ResearchLow
Contraindications
- Human therapeutic useRegulatory/safetyHigh
Adverse Effects
- Unknown systemic effectsGeneralUnknown
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- All clinical populationsRegulatory / SafetyAbsolute
Regulatory Status
- European UnionUnapprovedNot approved by EMA.
- United StatesUnapprovedNot approved by FDA; available only as a research chemical.
- United KingdomUnapprovedNot approved by MHRA.
No approved therapeutic indication in any major jurisdiction. Used as a research/reference compound. Not listed as an approved drug by FDA, EMA, or MHRA.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is S-Methyl glutathione?
S-Methylglutathione is a methylated analogue of the endogenous tripeptide glutathione (γ‑glutamyl‑cysteinyl‑glycine), where the cysteine thiol is methylated. It occurs as a metabolic product and is used primarily as a biochemical marker rather than a therapeutic agent.
What is S-Methyl glutathione used for?
S-Methyl glutathione is educationally associated with: Glutathione metabolism tracer, Glutathione S-transferase substrate/inhibitor research, Antioxidant defense modulation. Educational only — not medical advice.
How is S-Methyl glutathione administered?
Recorded routes of administration: Research Use Only (in Vitro / Ex Vivo).
What are the potential side effects of S-Methyl glutathione?
Reported adverse effects include: Unknown systemic effects. This list is not exhaustive — consult a qualified clinician.
Who should avoid S-Methyl glutathione?
Recorded contraindications: Human therapeutic use. Consult a qualified clinician before use.