S-octylglutathione
Also known as: GS-8, GSO8, octyl-GSH, S-n-octylglutathione, S-Octylglutathione, γ-Glu-Cys(S-octyl)-Gly
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Summary
S-octylglutathione is a synthetic alkylated derivative of the tripeptide glutathione designed to increase cellular uptake and act as an antioxidant in experimental settings.
Mechanism of Action
Membrane-permeable antioxidant; replenishes intracellular glutathione levels
Routes of Administration
Goals & Uses
- Antiproliferative / anticancer activityOncology / ResearchLow
- Protein farnesyltransferase inhibitionEnzyme Inhibition / ResearchModerate
- Glyoxalase I inhibitionEnzyme Inhibition / Biochemical ToolHigh
- Glutathione S-transferase inhibitionEnzyme Inhibition / ResearchModerate
- Intracellular glutathione supplementation modelRedox Biology / ResearchModerate
Contraindications
- Human/clinical useRegulatory / SafetyHigh
Adverse Effects
- Cytotoxicity at high concentrationsIn Vitro ToxicityCommon
- Oxidative stress perturbationRedox DisruptionUnknown
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- All human populationsGeneralAbsolute
Regulatory Status
- European UnionUnapprovedNo marketing authorization; used solely in laboratory research.
- United StatesUnapprovedInvestigational reagent, not approved for clinical use.
- United KingdomUnapprovedNo regulatory approval; research use only.
Not approved by any regulatory agency for clinical use. Used exclusively as a biochemical research reagent. Not classified as an investigational new drug (IND) in any known regulatory jurisdiction.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is S-octylglutathione?
S-octylglutathione is a synthetic alkylated derivative of the tripeptide glutathione designed to increase cellular uptake and act as an antioxidant in experimental settings.
What is S-octylglutathione used for?
S-octylglutathione is educationally associated with: Antiproliferative / anticancer activity, Protein farnesyltransferase inhibition, Glyoxalase I inhibition, Glutathione S-transferase inhibition, Intracellular glutathione supplementation model. Educational only — not medical advice.
How is S-octylglutathione administered?
Recorded routes of administration: Cell Culture, In Vitro (cell Culture), Intraperitoneal, Intravenous.
What are the potential side effects of S-octylglutathione?
Reported adverse effects include: Cytotoxicity at high concentrations, Oxidative stress perturbation. This list is not exhaustive — consult a qualified clinician.
Who should avoid S-octylglutathione?
Recorded contraindications: Human/clinical use. Consult a qualified clinician before use.