Angiotensin 1-7
Also known as: A(1-7), Ang-(1-7), Angiotensin-(1-7), Asp1-Ang-(1-7), AVE0991 (Mas agonist analog), Mas agonist peptide, TXA127
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Summary
Angiotensin 1‑7 (Ang‑(1‑7)) is a seven‑amino‑acid peptide of the renin‑angiotensin system that acts as a Mas‑receptor agonist. It is investigated for cardiovascular, renal and pulmonary indications but has no approved therapeutic use.
Mechanism of Action
Activates the Mas (Mas1) receptor, producing vasodilation, anti‑fibrotic, anti‑inflammatory and natriuretic effects that counteract Angiotensin II signaling.
Routes of Administration
Goals & Uses
- COVID-19 / Acute Lung InjuryPulmonary / Infectious DiseaseModerate
- HypertensionCardiovascularModerate
- Anti-cancer / Tumor SuppressionOncologyLow
- Renoprotection / Chronic Kidney DiseaseRenalModerate
- Hematopoietic RecoveryHematologyModerate
- Metabolic / Insulin SensitizationMetabolicLow
- COVID‑19 ARDSRespiratoryLow
- Pulmonary hypertensionCardiovascularModerate
- Cardioprotection / Heart failureCardiovascularModerate
Contraindications
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Hypersensitivity to Angiotensin 1-7 or excipientsAllergy / ImmunologicHigh
- Severe hypotensionCardiovascularHigh
Adverse Effects
- Injection site reactionsLocalCommon
- HeadacheNeurologicUnknownPain in the head or upper neck
- HypotensionCardiovascularUnknownLow blood pressure
- FlushingVascularUncommonWarmth and redness of the skin
- DizzinessNeurologicUnknownFeeling faint, lightheaded, or unsteady
- BradycardiaCardiovascularRare
Drug Interactions
- Antihypertensive agentsModerate
- Angiotensin Receptor Blockers (ARBs)Low
- Angiotensin II Receptor Blockers (ARBs, e.g., losartan)Moderate
- NSAIDsLowMay increase renal risk in susceptible patients
- ACE inhibitorsModerate
- ACE Inhibitors (e.g., enalapril, lisinopril)Moderate
Population Constraints
- Patients with baseline hypotensionCardiovascularRelative
- Severe renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- ElderlyAgeRelative
- Pregnant womenReproductiveRelative
- ChildrenPediatricRelative
Regulatory Status
- European UnionInvestigationalClinical studies ongoing.
- United StatesInvestigationalUnder IND for cardiovascular trials.
- United KingdomInvestigationalBeing evaluated in Phase 2 studies.
Not approved for clinical use in any jurisdiction; currently studied in Phase 1‑2 clinical trials.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Angiotensin 1-7?
Angiotensin 1‑7 (Ang‑(1‑7)) is a seven‑amino‑acid peptide of the renin‑angiotensin system that acts as a Mas‑receptor agonist. It is investigated for cardiovascular, renal and pulmonary indications but has no approved therapeutic use.
What is Angiotensin 1-7 used for?
Angiotensin 1-7 is educationally associated with: COVID-19 / Acute Lung Injury, Hypertension, Anti-cancer / Tumor Suppression, Renoprotection / Chronic Kidney Disease, Hematopoietic Recovery, Metabolic / Insulin Sensitization, COVID‑19 ARDS, Pulmonary hypertension, Cardioprotection / Heart failure. Educational only — not medical advice.
How is Angiotensin 1-7 administered?
Recorded routes of administration: Inhalation, Intravenous, Subcutaneous.
What are the potential side effects of Angiotensin 1-7?
Reported adverse effects include: Injection site reactions, Headache, Hypotension, Flushing, Dizziness, Bradycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Angiotensin 1-7?
Recorded contraindications: Pregnancy, Hypersensitivity to Angiotensin 1-7 or excipients, Severe hypotension. Consult a qualified clinician before use.