Angiotensinamide
Also known as: Ang II (1‑8) amide, Angiotensin II amide, Angiotensinamide, Angiotonin, Hypertensin, Val5-angiotensin II amide
Source Angiotensinamide at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Angiotensinamide (angiotensin II amide) is an 8‑residue peptide analogue of angiotensin II with a C‑terminal amide; it acts as a potent AT1 receptor agonist used mainly in experimental and diagnostic settings.
Mechanism of Action
agonist of angiotensin II type 1 (AT1) receptor, causing vasoconstriction and aldosterone release
Routes of Administration
Goals & Uses
- Pharmacological research toolResearchHigh
- Diagnostic assessment of renin‑angiotensin systemDiagnosticLow
- Acute elevation of blood pressureCardiovascularModerate
- Vasopressor support in distributive shockHemodynamic SupportModerate
- Treatment of refractory hypotensionHemodynamic SupportModerate
Contraindications
- HypervolemiaFluid BalanceModerate
- HypertensionCardiovascularHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Known hypersensitivity to angiotensin analogsAllergy/ImmunologyHigh
- Severe hypertensionCardiovascularHigh
Adverse Effects
- Oliguria / renal impairmentRenalUncommon
- Hypertension / hypertensive crisisCardiovascularCommon
- HypertensionCardiovascularCommonHigh blood pressure
- HeadacheNeurologicUncommonPain in the head or upper neck
- TachycardiaCardiovascularCommonAbnormally fast heart rate
- Hyperkalemia or hypokalemiaMetabolicUncommon
- BradycardiaCardiovascularCommon
Drug Interactions
- AT1 receptor blockers (ARBs)High
- Angiotensin Receptor Blockers (ARBs)High
- Other vasopressors (e.g., norepinephrine, vasopressin)Moderate
- ACE inhibitorsModerate
Population Constraints
- PregnancyReproductive SafetyAbsolute
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- ElderlyAgeRelative
- Elderly patientsAgeRelative
Regulatory Status
- European UnionUnapprovedClassified as a research chemical; no marketing authorization.
- United StatesUnapprovedAvailable only for research use; not FDA‑approved for therapeutic indication.
- United KingdomUnapprovedNot licensed for clinical use.
Angiotensinamide was previously approved and marketed in some jurisdictions (notably Europe and parts of the Americas) under the brand name Hypertensin for vasopressor use. It is no longer widely commercially available and is considered largely withdrawn or discontinued in most markets. Synthetic angiotensin II has been re-investigated and re-approved in the US (as giapreza) but angiotensinamide specifically is not the same formulation.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Angiotensinamide?
Angiotensinamide (angiotensin II amide) is an 8‑residue peptide analogue of angiotensin II with a C‑terminal amide; it acts as a potent AT1 receptor agonist used mainly in experimental and diagnostic settings.
What is Angiotensinamide used for?
Angiotensinamide is educationally associated with: Pharmacological research tool, Diagnostic assessment of renin‑angiotensin system, Acute elevation of blood pressure, Vasopressor support in distributive shock, Treatment of refractory hypotension. Educational only — not medical advice.
How is Angiotensinamide administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of Angiotensinamide?
Reported adverse effects include: Oliguria / renal impairment, Hypertension / hypertensive crisis, Hypertension, Headache, Tachycardia, Hyperkalemia or hypokalemia, Bradycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Angiotensinamide?
Recorded contraindications: Hypervolemia, Hypertension, Pregnancy, Known hypersensitivity to angiotensin analogs, Severe hypertension. Consult a qualified clinician before use.