Enalaprilat
Also known as: Enalapril diacid, Enalaprilat, Enalaprilate, MK-422, Vasotec IV
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Summary
Enalaprilat is the active diacid metabolite of enalapril; administered intravenously for acute hypertension and heart failure. It lowers blood pressure by inhibiting ACE.
Mechanism of Action
Competitive inhibition of angiotensin‑converting enzyme, preventing conversion of angiotensin I to angiotensin II and reducing aldosterone secretion
Routes of Administration
Goals & Uses
- Heart failureCardiovascularHigh
- Acute renal protectionRenalModerate
- HypertensionCardiovascularHigh
- Reduction of proteinuria in renal diseaseRenalModerate
- Hypertensive emergency/urgency managementCardiovascularHigh
- Heart failure management (acute)CardiovascularModerate
- Blood pressure control in hospitalized patientsCardiovascularHigh
Contraindications
- History of angioedema related to ACE inhibitorsImmunologicHigh
- Hereditary or idiopathic angioedemaImmunologic/AllergicHigh
- Hypersensitivity to enalaprilat or any ACE inhibitorHypersensitivityHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Pregnancy (2nd and 3rd trimester)ObstetricHigh
- Concomitant use with sacubitril/valsartanDrug InteractionHigh
- History of ACE inhibitor-induced angioedemaImmunologic/AllergicHigh
- Bilateral renal artery stenosisVascular/RenalHigh
- Severe bilateral renal artery stenosisRenalHigh
Adverse Effects
- Injection site reactionsLocalUncommon
- CoughRespiratoryCommonPersistent or episodic cough
- Acute kidney injuryRenalUncommonSudden decline in kidney function
- HypotensionCardiovascularCommonLow blood pressure
- Renal impairmentRenalUncommon
- Headache / dizzinessNeurologicalCommon
- HyperkalemiaElectrolyte ImbalanceCommon
- AngioedemaImmunologicRare
Drug Interactions
- Non‑steroidal anti‑inflammatory drugs (NSAIDs)Moderate
- Potassium-sparing diuretics / potassium supplementsModerate
- Diuretics (loop/thiazide)Moderate
- Sacubitril/valsartan (Entresto)High
- Potassium‑sparing diuretics (e.g., spironolactone)Moderate
- AliskirenHigh
- NSAIDsModerateMay increase renal risk in susceptible patients
- LithiumHigh
Population Constraints
- PregnancyReproductive SafetyAbsolute
- Bilateral renal artery stenosis or single functioning kidney with renal artery stenosisRenalAbsolute
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveAbsolute
- Neonates and infants (premature/newborn)PediatricAbsolute
- Severe renal impairment (eGFR <30 mL/min)RenalRelative
Regulatory Status
- European UnionApprovedApproved: Hypertensive emergencies, Heart failureApproved for IV use; same indications as US
- United StatesApprovedApproved: Acute hypertension, Acute decompensated heart failureIV formulation (Enalaprilat) approved; oral enalapril is the prodrug
- United KingdomApprovedApproved: Hypertensive emergencies, Acute heart failureAvailable under prescription as Enalaprilat injection
Not orally bioavailable; approved for intravenous use only in most jurisdictions.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Enalaprilat?
Enalaprilat is the active diacid metabolite of enalapril; administered intravenously for acute hypertension and heart failure. It lowers blood pressure by inhibiting ACE.
What is Enalaprilat used for?
Enalaprilat is educationally associated with: Heart failure, Acute renal protection, Hypertension, Reduction of proteinuria in renal disease, Hypertensive emergency/urgency management, Heart failure management (acute), Blood pressure control in hospitalized patients. Educational only — not medical advice.
How is Enalaprilat administered?
Recorded routes of administration: Intravenous.
What are the potential side effects of Enalaprilat?
Reported adverse effects include: Injection site reactions, Cough, Acute kidney injury, Hypotension, Renal impairment, Headache / dizziness, Hyperkalemia, Angioedema. This list is not exhaustive — consult a qualified clinician.
Who should avoid Enalaprilat?
Recorded contraindications: History of angioedema related to ACE inhibitors, Hereditary or idiopathic angioedema, Hypersensitivity to enalaprilat or any ACE inhibitor, Pregnancy, Pregnancy (2nd and 3rd trimester), Concomitant use with sacubitril/valsartan, History of ACE inhibitor-induced angioedema, Bilateral renal artery stenosis, Severe bilateral renal artery stenosis. Consult a qualified clinician before use.