Buserelin
Also known as: Buserelin acetate, D-Ser(tBu)6-des-Gly10-GnRH-ethylamide, Ferring 3611, HOE-766, Profact, Receptal, Suprefact
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Summary
Buserelin is a decapeptide GnRH analogue used to control gonadotropin release for assisted reproduction, treatment of hormone‑dependent cancers and endometriosis.
Mechanism of Action
Synthetic GnRH agonist that initially stimulates then down‑regulates pituitary GnRH receptors, leading to marked suppression of LH and FSH secretion.
Routes of Administration
Goals & Uses
- Controlled ovarian stimulation / ARTReproductive MedicineHigh
- Induction of ovulation for IVFReproductiveHigh
- Precocious pubertyPediatric EndocrinologyModerate
- Prostate cancer treatment (androgen deprivation)OncologyHigh
- Management of endometriosisGynecologyModerate
- Uterine fibroids (leiomyomata)GynecologyHigh
- Androgen suppression in prostate cancerOncologyModerate
- Endometriosis managementGynecologyHigh
- Gender-affirming hormone therapy (puberty suppression)EndocrinologyModerate
Contraindications
- Hypersensitivity to GnRH or analoguesImmunologicalHigh
- Severe hepatic impairmentOrganModerateLiver function concerns
- Osteoporosis (pre-existing severe)MusculoskeletalModerate
- Undiagnosed vaginal bleedingGynecologicalHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Breast cancer (estrogen‑dependent)OncologyHigh
- BreastfeedingPopulationModeratePotential transfer into breast milk or insufficient safety data
Adverse Effects
- Hot flushes / vasomotor symptomsEndocrine/VasomotorCommon
- Injection site reactionsLocalCommon
- Injection site painLocalCommonPain at the injection site
- HeadacheNeurologicCommonPain in the head or upper neck
- Decreased bone mineral densityMusculoskeletalCommon
- Hot flashesEndocrine / VasomotorCommon
- Mood changes / depressionPsychiatricUncommon
- Sexual dysfunction / loss of libidoSexual HealthCommon
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- Tumor flare (prostate cancer)OncologicalUncommon
Drug Interactions
- Estrogen‑containing contraceptivesModerate
- Gonadotropins (FSH/LH preparations)Low
- CYP3A4 inhibitors (e.g., ketoconazole)Low
- Insulin / antidiabetic agentsModerate
- QT-prolonging agentsModerate
- Anti-androgens (e.g., flutamide, bicalutamide)Low
Population Constraints
- Patients with depression or psychiatric historyPsychiatricRelative
- Elderly patients with cardiovascular diseaseCardiovascularRelative
- Pediatric patientsAgeRelative
- Elderly (>75 years)GeriatricRelative
- Patients with osteopenia/osteoporosisMusculoskeletalRelative
- Pediatric use (prepubertal / early pubertal)AgeRelative
Regulatory Status
- European UnionApprovedApproved: infertility treatment, prostate cancer, endometriosisMarketed under brand Suprefact.
- United StatesUnapprovedNot FDA‑approved; used off‑label in clinical trials.
- United KingdomApprovedApproved: infertility, prostate cancerAvailable via specialist prescription.
Approved in the EU, UK and many non‑US markets; not FDA‑approved in the United States.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Buserelin?
Buserelin is a decapeptide GnRH analogue used to control gonadotropin release for assisted reproduction, treatment of hormone‑dependent cancers and endometriosis.
What is Buserelin used for?
Buserelin is educationally associated with: Controlled ovarian stimulation / ART, Induction of ovulation for IVF, Precocious puberty, Prostate cancer treatment (androgen deprivation), Management of endometriosis, Uterine fibroids (leiomyomata), Androgen suppression in prostate cancer, Endometriosis management, Gender-affirming hormone therapy (puberty suppression). Educational only — not medical advice.
How is Buserelin administered?
Recorded routes of administration: Implant, Intramuscular, Intranasal, Intravenous, Nasal, Subcutaneous.
What are the potential side effects of Buserelin?
Reported adverse effects include: Hot flushes / vasomotor symptoms, Injection site reactions, Injection site pain, Headache, Decreased bone mineral density, Hot flashes, Mood changes / depression, Sexual dysfunction / loss of libido, Nausea, Tumor flare (prostate cancer). This list is not exhaustive — consult a qualified clinician.
Who should avoid Buserelin?
Recorded contraindications: Hypersensitivity to GnRH or analogues, Severe hepatic impairment, Osteoporosis (pre-existing severe), Undiagnosed vaginal bleeding, Pregnancy, Breast cancer (estrogen‑dependent), Breastfeeding. Consult a qualified clinician before use.