Cetrorelix
Also known as: cetrorelix, Cetrorelix acetate, Cetrotide, SB-75
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Summary
Cetrorelix is a synthetic GnRH antagonist used to prevent premature luteinizing hormone surges during controlled ovarian stimulation in assisted reproductive technology.
Mechanism of Action
Competitive antagonist at pituitary GnRH receptors, suppressing LH and FSH secretion
Routes of Administration
Goals & Uses
- Prevention of premature LH surge during IVFReproductive EndocrinologyHigh
- Prostate cancerOncologyLow
- Controlled ovarian hyperstimulation supportReproductive EndocrinologyHigh
- Prevent premature LH surgeReproductiveHigh
- Uterine fibroidsGynecologyLow
- Endometriosis treatmentGynecologyLow
Contraindications
- Moderate to severe hepatic impairmentHepaticModerate
- Severe renal impairmentOrganHighKidney function concerns
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Hypersensitivity to cetrorelix or excipientsAllergicModerate
- BreastfeedingPopulationHighPotential transfer into breast milk or insufficient safety data
- Hypersensitivity to cetrorelix or extrinsic peptide hormonesAllergyHigh
Adverse Effects
- Injection site reactionsLocalCommon
- HeadacheNeurologicUncommonPain in the head or upper neck
- Hot flashesEndocrine / VasomotorUncommon
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- Allergic/anaphylactic reactionsImmunologicalRare
- Hot flushesVasomotorCommon
- Ovarian hyperstimulation syndrome (OHSS)ReproductiveUncommon
Drug Interactions
- hCG (human chorionic gonadotropin)Moderate
- Gonadotropins (FSH, hMG)Low
- GnRH agonistsHigh
- Other GnRH analoguesModerate
Population Constraints
- Pediatric patientsAgeAbsolute
- Women with known latex allergyAllergyRelative
- MenSexAbsolute
- Patients with renal impairmentOrgan ImpairmentRelative
- ChildrenPediatricAbsolute
- Postmenopausal womenReproductive StatusAbsolute
Regulatory Status
- European UnionApprovedApproved: Assisted reproductive technology protocolsEMA approved
- United StatesApprovedApproved: Controlled ovarian stimulation in IVFFDA approved as Cetrotide
- United KingdomApprovedApproved: IVF ovarian stimulationMHRA approved
Approved in the US, EU, and UK for use in in vitro fertilization protocols; indicated for women undergoing ovarian stimulation.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Cetrorelix?
Cetrorelix is a synthetic GnRH antagonist used to prevent premature luteinizing hormone surges during controlled ovarian stimulation in assisted reproductive technology.
What is Cetrorelix used for?
Cetrorelix is educationally associated with: Prevention of premature LH surge during IVF, Prostate cancer, Controlled ovarian hyperstimulation support, Prevent premature LH surge, Uterine fibroids, Endometriosis treatment. Educational only — not medical advice.
How is Cetrorelix administered?
Recorded routes of administration: Subcutaneous.
What are the potential side effects of Cetrorelix?
Reported adverse effects include: Injection site reactions, Headache, Hot flashes, Nausea, Allergic/anaphylactic reactions, Hot flushes, Ovarian hyperstimulation syndrome (OHSS). This list is not exhaustive — consult a qualified clinician.
Who should avoid Cetrorelix?
Recorded contraindications: Moderate to severe hepatic impairment, Severe renal impairment, Pregnancy, Hypersensitivity to cetrorelix or excipients, Breastfeeding, Hypersensitivity to cetrorelix or extrinsic peptide hormones. Consult a qualified clinician before use.