Triptorelin
Also known as: AY-25650, D-Trp6-LHRH, Decapeptyl, Diphereline, Gonapeptyl, Trelstar, Triptorelin acetate
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Summary
Triptorelin is a synthetic GnRH analogue used to achieve medical gonadotropin suppression in prostate cancer, endometriosis, precocious puberty, assisted reproduction and certain breast cancers.
Mechanism of Action
Continuous stimulation of pituitary GnRH receptors causing down‑regulation of LH/FSH secretion and subsequent suppression of sex steroid production.
Routes of Administration
Goals & Uses
- Prostate cancerOncologyHigh
- Prostate cancer treatmentOncologyHigh
- Central precocious pubertyPediatric EndocrinologyHigh
- Uterine fibroid reductionGynecologyHigh
- Precocious pubertyPediatric EndocrinologyHigh
- Fertility preservation / controlled ovarian stimulationReproductive MedicineModerate
- Endometriosis managementGynecologyHigh
- Breast cancer (hormone‑sensitive)OncologyModerate
- EndometriosisGynecologyHigh
- Gender-affirming hormone therapyEndocrinologyModerate
- Assisted reproductionFertilityHigh
Contraindications
- Spinal cord compression or urinary obstructionUrological/neurologicalHigh
- Hypersensitivity to triptorelin or formulation excipientsImmunologicModerate
- Severe hepatic impairmentOrganModerateLiver function concerns
- Undiagnosed vaginal bleedingGynecologicalModerate
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Hypersensitivity to GnRH, GnRH analogs, or triptorelinAllergyHigh
- BreastfeedingPopulationHighPotential transfer into breast milk or insufficient safety data
Adverse Effects
- Mood changes (depression, anxiety)PsychiatricUncommon
- Injection site reactionsLocalCommon
- Injection site painLocalCommonPain at the injection site
- Decreased bone mineral densityMusculoskeletalCommon
- Decreased libidoSexual / EndocrineCommon
- Hot flashesEndocrine / VasomotorCommon
- Bone mineral density lossSkeletalUncommon
- Erectile dysfunction / decreased libidoSexualCommon
- Hot flushes/flashesVasomotorCommon
- Testosterone flareEndocrineCommon
- Cardiovascular events (QT prolongation, metabolic syndrome)Cardiovascular/metabolicUncommon
Drug Interactions
- CYP3A4 inducers (e.g., rifampin)Low
- Antidiabetic agentsModerate
- Estrogen replacement therapyModerate
- Antiandrogens (e.g., bicalutamide)Low
- QT-prolonging agents (e.g., antiarrhythmics, antipsychotics)High
- Warfarin / anticoagulantsModerate
Population Constraints
- Elderly patients with cardiovascular diseaseCardiovascularRelative
- Pediatric patients (non-precocious puberty use)AgeRelative
- Pediatric patients (precocious puberty)AgeRelative
- Patients with diabetes mellitusMetabolicRelative
- Patients with osteoporosisMusculoskeletalRelative
- Pregnant womenReproductiveAbsolute
Regulatory Status
- European UnionApprovedApproved: prostate cancer, endometriosis, precocious puberty, assisted reproduction, breast cancerMultiple depot formulations.
- United StatesApprovedApproved: prostate cancer, endometriosis, precocious puberty, assisted reproductionMarketed as Trelstar.
- United KingdomApprovedApproved: prostate cancer, endometriosis, precocious puberty, assisted reproductionSame as EU.
Approved in the US, EU and UK in depot injection formulations (e.g., 1‑month, 3‑month, 6‑month). Marketed under several brand names.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Triptorelin?
Triptorelin is a synthetic GnRH analogue used to achieve medical gonadotropin suppression in prostate cancer, endometriosis, precocious puberty, assisted reproduction and certain breast cancers.
What is Triptorelin used for?
Triptorelin is educationally associated with: Prostate cancer, Prostate cancer treatment, Central precocious puberty, Uterine fibroid reduction, Precocious puberty, Fertility preservation / controlled ovarian stimulation, Endometriosis management, Breast cancer (hormone‑sensitive), Endometriosis, Gender-affirming hormone therapy, Assisted reproduction. Educational only — not medical advice.
How is Triptorelin administered?
Recorded routes of administration: Intramuscular, Subcutaneous.
What are the potential side effects of Triptorelin?
Reported adverse effects include: Mood changes (depression, anxiety), Injection site reactions, Injection site pain, Decreased bone mineral density, Decreased libido, Hot flashes, Bone mineral density loss, Erectile dysfunction / decreased libido, Hot flushes/flashes, Testosterone flare, Cardiovascular events (QT prolongation, metabolic syndrome). This list is not exhaustive — consult a qualified clinician.
Who should avoid Triptorelin?
Recorded contraindications: Spinal cord compression or urinary obstruction, Hypersensitivity to triptorelin or formulation excipients, Severe hepatic impairment, Undiagnosed vaginal bleeding, Pregnancy, Hypersensitivity to GnRH, GnRH analogs, or triptorelin, Breastfeeding. Consult a qualified clinician before use.