Deslorelin
Also known as: D-His(Bzl)6-des-Gly10-GnRH ethylamide, Deslorelin, Deslorelin acetate, Ovuplant, STL-801, Suprelorin
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Summary
Deslorelin is a synthetic GnRH agonist used primarily as a veterinary implant for temporary contraception and management of reproductive disorders in dogs, cats, and ferrets. It is investigational in humans for hormone‑dependent conditions.
Mechanism of Action
Synthetic decapeptide analog of GnRH that binds GnRH receptors, causing an initial surge of LH/FSH followed by receptor desensitization and suppression of gonadal steroidogenesis.
Routes of Administration
Goals & Uses
- Suppression of precocious pubertyEndocrinology / PediatricsModerate
- investigational treatment of prostate cancerHumanLow
- Gender-affirming puberty suppression (transgender youth)Endocrinology / Gender MedicineModerate
- Prostate cancer palliationOncologyLow
- estrus control in ferretsVeterinaryModerate
- temporary contraception in dogsVeterinaryHigh
- Endometriosis treatmentGynecologyModerate
- management of benign prostatic hyperplasia in dogsVeterinaryModerate
- Veterinary fertility control (male dogs)Veterinary MedicineHigh
Contraindications
- hypersensitivity to deslorelin or formulation componentsAllergicModerate
- Undiagnosed vaginal bleedingGynecologicalModerate
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- pregnancy (animals)ReproductiveHigh
- Hypersensitivity to GnRH or GnRH analogsAllergy / ImmunologyHigh
- Known or suspected hormone-sensitive malignancy (non-prostate, non-target)OncologyModerate
Adverse Effects
- Hot flashes / vasomotor symptomsAutonomic / ThermoregulatoryCommon
- Injection/implant site reactionsDermatological / LocalCommon
- AnaphylaxisImmunologicRareSevere life-threatening allergic reaction
- Decreased bone mineral densityMusculoskeletalCommon
- Hot flashesEndocrine / VasomotorRare
- vaginal bleeding (animals)ReproductiveUncommon
- Injection site swellingLocalCommonSwelling at the injection site
- Mood changes / depressionPsychiatricUncommon
- Hormone flare (initial testosterone/estradiol surge)EndocrineCommon
Drug Interactions
- Androgen or estrogen supplementationModerate
- antiandrogensLow
- Antidiabetic agentsLow
- QT-prolonging agentsModerate
- combined hormonal contraceptivesModerate
Population Constraints
- Osteoporosis or low bone densityMusculoskeletalRelative
- breeding animalsVeterinaryAbsolute
- Pediatric patients (prepubertal)AgeRelative
- Patients with cardiovascular diseaseComorbidityRelative
- BreastfeedingReproductiveRelative
- ChildrenPediatricRelative
Regulatory Status
- European UnionApprovedApproved: temporary contraception in dogs, estrus control in ferretsAuthorized for veterinary use under EU veterinary medicines directive.
- United StatesInvestigationalInvestigational human trials for prostate cancer and endometriosis; not FDA‑approved for human use.
- United KingdomApprovedApproved: Temporary suppression of fertility in male dogs (veterinary)Veterinary approval maintained post-Brexit. Human use in gender clinics (e.g., NHS) has occurred under specialist oversight.
Approved for veterinary use in the US, EU and other jurisdictions (e.g., Suprelorin® implant). Not approved for human therapeutic use.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Deslorelin?
Deslorelin is a synthetic GnRH agonist used primarily as a veterinary implant for temporary contraception and management of reproductive disorders in dogs, cats, and ferrets. It is investigational in humans for hormone‑dependent conditions.
What is Deslorelin used for?
Deslorelin is educationally associated with: Suppression of precocious puberty, investigational treatment of prostate cancer, Gender-affirming puberty suppression (transgender youth), Prostate cancer palliation, estrus control in ferrets, temporary contraception in dogs, Endometriosis treatment, management of benign prostatic hyperplasia in dogs, Veterinary fertility control (male dogs). Educational only — not medical advice.
How is Deslorelin administered?
Recorded routes of administration: Intramuscular, Intravenous, Subcutaneous, Subcutaneous Implant, Subcutaneous Injection.
What are the potential side effects of Deslorelin?
Reported adverse effects include: Hot flashes / vasomotor symptoms, Injection/implant site reactions, Anaphylaxis, Decreased bone mineral density, Hot flashes, vaginal bleeding (animals), Injection site swelling, Mood changes / depression, Hormone flare (initial testosterone/estradiol surge). This list is not exhaustive — consult a qualified clinician.
Who should avoid Deslorelin?
Recorded contraindications: hypersensitivity to deslorelin or formulation components, Undiagnosed vaginal bleeding, Pregnancy, pregnancy (animals), Hypersensitivity to GnRH or GnRH analogs, Known or suspected hormone-sensitive malignancy (non-prostate, non-target). Consult a qualified clinician before use.