Gonadorelin
Also known as: Cystorelin, Factrel, GnRH, Gonadorelin, Gonadorelin acetate, Gonadotropin‑releasing hormone, Kryptocur, LHRH, Lutrepulse
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Summary
Synthetic GnRH (gonadorelin) is used primarily as a diagnostic agent to assess pituitary gonadotropin reserve and, in some regions, to trigger ovulation in infertility protocols.
Mechanism of Action
Agonist at the GnRH receptor on anterior pituitary gonadotrophs, stimulating release of LH and FSH
Routes of Administration
Goals & Uses
- Stimulate LH and FSH releaseEndocrine ActivationHigh
- Treatment of hypogonadotropic hypogonadism (male)EndocrinologyModerate
- Treatment of hypothalamic amenorrhea / induction of ovulationReproductive EndocrinologyHigh
- Trigger ovulation in assisted reproductionTherapeuticModerate
- Preservation of testicular function during exogenous androgen usePerformance / Andrology (off Label)Low
- Diagnostic assessment of pituitary gonadotropin reserveDiagnosticHigh
- Pituitary function diagnostic testDiagnosticHigh
- Cryptorchidism treatmentPediatric UrologyModerate
Contraindications
- Known hypersensitivity to gonadorelin or formulation excipientsAllergicHigh
- Conditions exacerbated by LH/FSH stimulation (e.g., hormone-sensitive tumors)OncologicHigh
- Hypersensitivity to gonadorelin or GnRH analoguesAllergy / ImmunologicHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Estrogen‑dependent neoplasms (e.g., breast, endometrial cancer)OncologicModerate
- Polycystic ovary syndrome (PCOS) in ovulation induction contextReproductiveModerate
Adverse Effects
- Injection site reactionsLocalCommon
- Multiple gestationReproductiveUncommon
- Anaphylaxis / hypersensitivityImmunologicRare
- Injection site painLocalCommonPain at the injection site
- HeadacheNeurologicUncommonPain in the head or upper neck
- FlushingVascularUncommonWarmth and redness of the skin
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- Ovarian hyperstimulation syndrome (OHSS)ReproductiveUncommon
Drug Interactions
- Exogenous androgens / anabolic steroidsModerate
- Estrogen‑containing oral contraceptivesModerate
- GnRH antagonists (e.g., cetrorelix, ganirelix)High
- Dopamine agonists (e.g., bromocriptine)Moderate
- DigoxinLow
- Dopamine agonists (e.g., bromocriptine, cabergoline)Low
Population Constraints
- Pediatric patientsAgeRelative
- Patients with pituitary tumorsOncologic / EndocrinologicRelative
- Pediatric patients (prepubertal)AgeRelative
- Pregnant womenReproductiveAbsolute
- Patients with ovarian cysts or enlarged ovariesReproductiveRelative
Regulatory Status
- European UnionApprovedApproved: diagnostic testing of pituitary functionAuthorized in several member states for similar diagnostic purposes.
- United StatesApprovedApproved: diagnostic testing of pituitary gonadotropin reserve, off‑label ovulation triggerMarketed as Gonadorelin acetate injection; FDA‑approved for diagnostic use.
- United KingdomApprovedApproved: diagnostic testing of pituitary gonadotropin reserveAvailable under the Human Medicines Regulations for diagnostic use.
Approved in the United States and several EU countries for diagnostic use; therapeutic indications are limited and often off‑label.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Gonadorelin?
Synthetic GnRH (gonadorelin) is used primarily as a diagnostic agent to assess pituitary gonadotropin reserve and, in some regions, to trigger ovulation in infertility protocols.
What is Gonadorelin used for?
Gonadorelin is educationally associated with: Stimulate LH and FSH release, Treatment of hypogonadotropic hypogonadism (male), Treatment of hypothalamic amenorrhea / induction of ovulation, Trigger ovulation in assisted reproduction, Preservation of testicular function during exogenous androgen use, Diagnostic assessment of pituitary gonadotropin reserve, Pituitary function diagnostic test, Cryptorchidism treatment. Educational only — not medical advice.
How is Gonadorelin administered?
Recorded routes of administration: Intranasal, Intravenous, Nasal, Subcutaneous.
What are the potential side effects of Gonadorelin?
Reported adverse effects include: Injection site reactions, Multiple gestation, Anaphylaxis / hypersensitivity, Injection site pain, Headache, Flushing, Nausea, Ovarian hyperstimulation syndrome (OHSS). This list is not exhaustive — consult a qualified clinician.
Who should avoid Gonadorelin?
Recorded contraindications: Known hypersensitivity to gonadorelin or formulation excipients, Conditions exacerbated by LH/FSH stimulation (e.g., hormone-sensitive tumors), Hypersensitivity to gonadorelin or GnRH analogues, Pregnancy, Estrogen‑dependent neoplasms (e.g., breast, endometrial cancer), Polycystic ovary syndrome (PCOS) in ovulation induction context. Consult a qualified clinician before use.